pentobarbital will lessen the level or influence of imatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unfamiliar.pentobarbital will lessen the level or result of buprenorphine subdermal implant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Check individuals by now on bup